Research

I’m passionate about using DNA to reconstruct the hidden stories of human and wildlife populations.

At FamilyTreeDNA I build the methods behind our ancestry, phylogenetics, and ancient DNA work. Alongside that I study the evolution and conservation of a threatened alpine toad in the Sierra Nevada. The two overlap more than you would expect: the corridor method behind Globetrekker’s migration maps came straight out of modelling how toads move between meadows.

>330,000complete mitogenomes in the largest human phylogeny yet described
>1.5Mgenotyped individuals in the autosomal database
>3,000hours of field research in Sierra Nevada toad meadows
25+papers, reports, and white papers

Five areas of work
Time-calibrated phylogeny of deep African mitochondrial lineages

Human phylogenetics at scale

The largest human family tree yet described, and the search methods that made a third of a million sequences tractable.

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Chromosome painting showing population ancestry segments

Ancestry inference

Turning a genotype into a map of where someone’s ancestors lived, and a defensible estimate of how they connect to everyone else.

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Map of triangulated ancestral locations inferred from ancient DNA

Ancient DNA and history

Beethoven’s hair, two Holy Roman Emperors, a Viking Age cemetery. Same question each time: who was this person?

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Chromosome painting across many individuals sharing a founder mutation

Population history and medical genetics

Where a rare disease mutation came from, how many priestly lineages there really are, and why one Greek peninsula never got replaced.

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Predicted migration corridors for the Yosemite toad under climate change

Evolution and conservation genomics

Fifteen years on a toad that breeds where the snow melts last, plus a Gila monster, a desert vole, and a Chinese conifer.

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Where the fieldwork happens
The Milky Way over upper Kerrick Canyon, northern Yosemite
Upper Kerrick Canyon before the Perseids, 2016
Montane and subalpine meadows used by breeding Yosemite toads
Montane and subalpine breeding meadows
Fieldwork in Goddard Canyon, Kings Canyon National Park
Goddard Canyon, Kings Canyon National Park

The people behind it
The FamilyTreeDNA research and development team
FamilyTreeDNA R&D
The Million Mito Project team
The Million Mito Project team

Almost none of this was done alone. Group photographs of the teams and cohorts I have worked with, at FamilyTreeDNA and at San Diego State, are on the Research Cohorts page.

Every paper, report, and white paper is listed on the Publications page.